State health policymakers know that improving health and controlling costs sometimes requires investment outside the bounds of medical care. With support from the Robert Wood Johnson Foundation, this brief explores Louisiana’s permanent supportive housing program. The program, administered jointly by the state’s Medicaid agency and housing authority, is a cross-agency partnership that braids funding to serve vulnerable cross-disability populations, address homelessness, reduce institutionalization, and save money for the state. The state’s ability to sustain the program over time suggests that it holds lessons for other policymakers interested in combining funds to sustainably support initiatives addressing the social determinants of health.